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Isocurcumenol

Cat. No. M14633
Isocurcumenol Structure
Size Price Availability Quantity
5mg USD 360  USD360 In stock
10mg USD 620  USD620 In stock
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Quality Control & Documentation
Biological Activity

Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively.

Chemical Information
Molecular Weight 234.33
CAS Number 24063-71-6
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yan Chen, et al. Cucurbituril and zwitterionic surfactant-based matrix solid-phase dispersion microextraction to simultaneously determine terpenoids from Radix Curcumae

[2] Ciqiong Chen, et al. Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum

[3] S Lakshmi, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells

[4] Mohd Aspollah Sukari, et al. Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana

[5] Jeoung-Hee Ha, et al. Modulation of radioligand binding to the GABA(A)-benzodiazepine receptor complex by a new component from Cyperus rotundus

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Keywords: Isocurcumenol supplier, Estrogen Receptor, inhibitors, activators


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