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Isepamicin

Cat. No. M40864
Isepamicin Structure
Synonym:

Sch 21420

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Biological Activity

Isepamicin is an aminoglycoside antibiotic derived from actinomycetes with an antimicrobial spectrum that includes Enterobacteriaceae and Staphylococcus spp. and has been shown to have improved activity against strains producing type I 6'-acetyltransferase.

Chemical Information
Molecular Weight 569.6
Formula C22H43N5O12
CAS Number 58152-03-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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