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Ipratropium Bromide

Cat. No. M3501
Ipratropium Bromide Structure
Synonym:

Sch 1000

Size Price Availability
100mg USD 270  USD300 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 ug/kg); the maximum effect was obtained with 1.0 ug/kg which doubled the bronchoconstriction. When the dose was increased above 1.0 ug/kg potentiation no longer occurred; instead the vagally induced bronchoconstriction was antagonised.<

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 412.37
Formula C20H30BrNO3
CAS Number 22254-24-6
Purity >98%
Solubility DMSO 80 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ipratropium Bromide, Sch 1000 supplier, AChR/AChE, inhibitors

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