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Insulin glargine

Cat. No. M22475
Insulin glargine Structure
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Biological Activity

Insulin glargine is a long-acting insulin analog. Insulin glargine can be used for the research of diabetes mellitus.

Chemical Information
Molecular Weight 6062.89
Formula C267H404N72O78S6
CAS Number 160337-95-1
Solubility (25°C) Soluble in acidic solution (pH 4)
Storage 4°C, do not freeze
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hiddo J L Heerspink, et al. Lancet Diabetes Endocrinol. Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial

[2] Florian K Zeugswetter, et al. J Vet Emerg Crit Care (San Antonio). Glargine versus regular insulin protocol in feline diabetic ketoacidosis

[3] Harpreet S Bajaj, et al. Diabetes Care. Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial

[4] Sheridan M Hoy. BioDrugs. MYL1501D Insulin Glargine: A Review in Diabetes Mellitus

[5] Hae-Gwang Hwang, et al. J Microbiol Biotechnol. Recombinant Glargine Insulin Production Process Using Escherichia coli

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