Insulin glargine is a long-acting insulin analog. Insulin glargine can be used for the research of diabetes mellitus.
|Solubility (25°C)||Soluble in acidic solution (pH 4)|
|Storage||4°C, do not freeze|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Hiddo J L Heerspink, et al. Lancet Diabetes Endocrinol. Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial
 Florian K Zeugswetter, et al. J Vet Emerg Crit Care (San Antonio). Glargine versus regular insulin protocol in feline diabetic ketoacidosis
 Harpreet S Bajaj, et al. Diabetes Care. Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial
 Sheridan M Hoy. BioDrugs. MYL1501D Insulin Glargine: A Review in Diabetes Mellitus
 Hae-Gwang Hwang, et al. J Microbiol Biotechnol. Recombinant Glargine Insulin Production Process Using Escherichia coli
|Dextran (Mw 150000)
Dextran is a multipurpose branched glucan, which can improve plasma colloid osmotic pressure, increase blood volume, reduce platelet adhesion, inhibit red blood cell aggregation, reduce blood viscosity, reduce peripheral circulation resistance, and unclog microcirculation.
Zeatin is a coconut milk-derived plant hormone and is a common plant cytokinin that is found in the developing or meristematic tissues and organs such as roots, shoot apex, immature organs, and others.
Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator.
|Poly-L-lysine (MW 15000~30000)
Poly-L-lysine (MW 15000~30000)
|Poly-L-lysine (MW 30000~70000)
Poly-L-lysine (MW 30000~70000)
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