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Insulin aspart

Cat. No. M22474
Insulin aspart Structure

B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14

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Biological Activity

Insulin aspart (B28Asp) is a fast-acting analog of human insulin. Insulin aspart can be used for researching diabetes. Insulin aspart provides more rapid absorption than regular human insulin.

Chemical Information
Molecular Weight 5825.53
Formula C256H381N65O79S6
CAS Number 116094-23-6
Solubility (25°C) Water 20 mg/mL (adjust pH to 3)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Elisabeth R Mathiesen, et al. Lancet Diabetes Endocrinol. Insulin degludec versus insulin detemir, both in combination with insulin aspart, in the treatment of pregnant women with type 1 diabetes (EXPECT): an open‑label, multinational, randomised, controlled, non-inferiority trial

[2] Roopa Mehta, et al. Diabetes Obes Metab. Practical use of insulin degludec/insulin aspart in a multinational setting: beyond the guidelines

[3] Hanne Haahr, et al. Clin Pharmacokinet. Fast-Acting Insulin Aspart: A Review of its Pharmacokinetic and Pharmacodynamic Properties and the Clinical Consequences

[4] Abigayle Davis, et al. Clin Pharmacokinet. Faster Insulin Aspart: A New Bolus Option for Diabetes Mellitus

[5] K L Simpson, et al. Drugs. Insulin aspart

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Keywords: Insulin aspart, B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14 supplier, inhibitors, activators

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