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Inosine

Cat. No. M10132
Inosine Structure
Synonym:

Atorel; HXR; Hypoxanthine D-riboside

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 36  USD36 In stock
1g USD 50  USD50 In stock
5g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose, with immunomodulatory, neuroprotective, and analgesic properties. Inosine stimulates axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models. Inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway.

Product Citations
Chemical Information
Molecular Weight 268.23
Formula C10H12N4O5
CAS Number 58-63-9
Solubility (25°C) Water 20 mg/mL
DMSO 25 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuhan Zhang, et al. Molecules. Inosine and D-Mannose Secreted by Drug-Resistant Klebsiella pneumoniae Affect Viability of Lung Epithelial Cells

[2] Stella Celio Junqueira, et al. Mol Neurobiol. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor

[3] J W Phillis, et al. J Cereb Blood Flow Metab. Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia

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Keywords: Inosine, Atorel; HXR; Hypoxanthine D-riboside supplier, Adenosine Receptor, inhibitors, activators


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