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Indolicidin TFA is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils. Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated. Indolicidin binds purified surface lipopolysaccharide with high affinity and permeabilized the outer membrane of Escherichia coli to the small hydrophobic molecule 1-N-phenylnapthylamine (Mr 200), results consistent with indolicidin crossing the outer membrane via the self-promoted uptake pathway.
Sequence: Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2
| Molecular Weight | 2020.31 |
| Formula | C102H133F3N26O15 |
| CAS Number | 140896-21-5 (free base) |
| Solubility (25°C) | Water ≥ 1 mg/mL |
| Storage | -20°C, dry, sealed |
[1] T J Falla, et al. J Biol Chem. Mode of action of the antimicrobial peptide indolicidin
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