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iMAC2 is a inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).
| Molecular Weight | 542.11 |
| Formula | C19H20Br2FN3.2HCl |
| CAS Number | 335166-00-2 |
| Solubility (25°C) | DMSO 2.71 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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