Ibuprofen arginine non-steroidal anti-inflammatory compound (NSAID) the more soluble form of ibuprofen arginine. Ibuprofen, like ibuprofen and its sodium salts, inhibits COX-2, but only ibuprofen can enhance the cellular NO pathway through the synergistic delivery of NOS substrate arginine. Ibuprofen, but not sodium, Shows reversing the inhibitory effect of Cardiotoxic hormone asymmetrically dimethylarginine (ADMA) and Ng-Nitro-L-Arginin ethyl ester (L-name) acted on nitric oxide synthase (Enos & Enol) in vitro (mouse RAW264.7 macrophages and isolated mouse and rat aorta) and effectively prevented l-name-induced increases in arterial blood pressure from large in vivo anesthesia Mice (0.5 mg/kg L - the NAME; Ibuprofen arginate 114.8 μmol/kg, equivalent to 20 mg/kg L-ARG through femoral artery intubation).
Molecular Weight | 380.48 |
Formula | C19H32N4O4 |
CAS Number | 57469-82-6 |
Solubility (25°C) | Water: 20 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Products |
---|
Isothiuronium
Isothiouronium is a functional group, it is the acid salt of isothiourea. |
Sultosilic acid, piperazine salt
Sultosilic acid piperazine salt is a compound with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically significant decrease of triglycerides, total cholesterol, beta- and pre-beta-cholesterol and an increase of alpha-cholesterol. |
Ipamorelin
Ipamorelin (NNC-26-0161) is a a novel and potent ghrelin mimetic peptide compound that counteracts glucocorticoid-induced decrease in bone formation of adult rats. |
PRGL493
PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. |
Hercynine
Hercynine is a natural product, found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees, and is a precursor of L-(+)-ergothioneine. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.