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Ibuprofen Arginate

Cat. No. M8697

All AbMole products are for research use only, cannot be used for human consumption.

Ibuprofen Arginate Structure

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Quality Control & Documentation
Biological Activity

Ibuprofen arginine non-steroidal anti-inflammatory compound (NSAID) the more soluble form of ibuprofen arginine. Ibuprofen, like ibuprofen and its sodium salts, inhibits COX-2, but only ibuprofen can enhance the cellular NO pathway through the synergistic delivery of NOS substrate arginine. Ibuprofen, but not sodium, Shows reversing the inhibitory effect of Cardiotoxic hormone asymmetrically dimethylarginine (ADMA) and Ng-Nitro-L-Arginin ethyl ester (L-name) acted on nitric oxide synthase (Enos & Enol) in vitro (mouse RAW264.7 macrophages and isolated mouse and rat aorta) and effectively prevented l-name-induced increases in arterial blood pressure from large in vivo anesthesia Mice (0.5 mg/kg L - the NAME; Ibuprofen arginate 114.8 μmol/kg, equivalent to 20 mg/kg L-ARG through femoral artery intubation).

Chemical Information
Molecular Weight 380.48
Formula C19H32N4O4
CAS Number 57469-82-6
Solubility (25°C) Water: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Juan Prez Cajaraville. Ibuprofen Arginate for Rapid-Onset Pain Relief in Daily Practice: A Review of Its Use in Different Pain Conditions

[2] B Ahmetaj-Shala, et al. Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing

[3] Nicholas S Kirkby, et al. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis

[4] Antonio Ortega-lvaro, et al. Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain

[5] Paul Desjardins, et al. Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen

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Keywords: Ibuprofen Arginate supplier, inhibitors, activators

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