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Ibufenac is a non-steroidal anti-inflammatory drug (NSAID) analog of ibuprofen that was withdrawn for hepatotoxicity. It inhibits cyclooxygenases COX-1 and -2 activity with IC50 values of 17.4 and 13.1 μM, respectively and > 40 μM for 5-LOX. It has been used in studies of drug-induced hepatotoxicity.
| Molecular Weight | 192.25 |
| Formula | C12H16O2 |
| CAS Number | 1553-60-2 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] F D HART, et al. IBUFENAC (4-ISOBUTYLPHENYL ACETIC ACID)
[2] No authors listed. Drug Ther Bull. Ibufenac (Dytransin) withdrawn
[3] No authors listed. Br Med J. Ibufenac
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