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Ibandronate sodium salt

Cat. No. M7858

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Ibandronate sodium salt Structure

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Quality Control & Documentation
Biological Activity

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.

Chemical Information
Molecular Weight 341.21
Formula C9H22NNaO7P2
CAS Number 138844-81-2
Solubility (25°C) Water: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] T Savaridas, et al. Effect of ibandronate on bending strength and toughness of rodent cortical bone: Possible implications for fracture prevention

[2] Joanna Biernacka, et al. Prediction of bioavailability of selected bisphosphonates using in silico methods towards categorization into a biopharmaceutical classification system

[3] Zbynek Oktabec, et al. Preparation and properties of new co-crystals of ibandronate with gluco- or galactopyranoside derivatives

[4] C Asche, et al. Predictors of oral bisphosphonate prescriptions in post-menopausal women with osteoporosis in a real-world setting in the USA

[5] Horst Claassen, et al. Extracellular matrix changes in knee joint cartilage following bone-active drug treatment

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Keywords: Ibandronate sodium salt supplier, inhibitors, activators

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