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Cat. No. M2762
Hyoscyamine Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
50mg USD 34  USD34 In stock
100mg USD 50  USD50 In stock
200mg USD 62  USD62 In stock
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Quality Control & Documentation
Biological Activity

Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.

Chemical Information
Molecular Weight 289.37
Formula C17H23NO3
CAS Number 101-31-5
Solubility (25°C) DMSO 48 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Prashanth Srinivasan, et al. Biosynthesis of medicinal tropane alkaloids in yeast

[2] No authors listed. Hyoscyamine

[3] No authors listed. Antiemetic Agents

[4] Neelesh Gupta. Hyoscyamine for a Slow Ventricular Response During Atrial Fibrillation

[5] Kathrin Laura Kohnen-Johannsen, et al. Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

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Keywords: Hyoscyamine, Daturine supplier, AChR/AChE, inhibitors, activators

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