Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
|Solubility (25°C)||DMSO 48 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Prashanth Srinivasan, et al. Biosynthesis of medicinal tropane alkaloids in yeast
 No authors listed. Hyoscyamine
 No authors listed. Antiemetic Agents
 Neelesh Gupta. Hyoscyamine for a Slow Ventricular Response During Atrial Fibrillation
 Kathrin Laura Kohnen-Johannsen, et al. Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production
|Related AChR/AChE Products|
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
Emraclidine (CVL-231) is a brain-penetrant muscarinic M4 receptor positive allosteric modulator. Emraclidine can be used for the research of neurological diseases.
ZSET1446 (ST101) is a novel cognitive enhancer that activates T-type voltage-gated calcium channels (VGCCs), and it significantly improves learning deficits in various types of Alzheimer disease (AD) models.
Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.
BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).
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