Free shipping on all orders over $ 500

Hyoscyamine

Cat. No. M2762
Hyoscyamine Structure
Synonym:

Daturine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
50mg USD 34  USD34 In stock
100mg USD 50  USD50 In stock
200mg USD 62  USD62 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.

Chemical Information
Molecular Weight 289.37
Formula C17H23NO3
CAS Number 101-31-5
Solubility (25°C) DMSO 48 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Prashanth Srinivasan, et al. Biosynthesis of medicinal tropane alkaloids in yeast

[2] No authors listed. Hyoscyamine

[3] No authors listed. Antiemetic Agents

[4] Neelesh Gupta. Hyoscyamine for a Slow Ventricular Response During Atrial Fibrillation

[5] Kathrin Laura Kohnen-Johannsen, et al. Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

Related AChR/AChE Products
(S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).

Emraclidine (CVL-231)

Emraclidine (CVL-231) is a brain-penetrant muscarinic M4 receptor positive allosteric modulator. Emraclidine can be used for the research of neurological diseases.

ZSET1446 (ST101)

ZSET1446 (ST101) is a novel cognitive enhancer that activates T-type voltage-gated calcium channels (VGCCs), and it significantly improves learning deficits in various types of Alzheimer disease (AD) models.

Varenicline dihydrochloride

Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.

BNC210

BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).

  Catalog
Abmole Inhibitor Catalog




Keywords: Hyoscyamine, Daturine supplier, AChR/AChE, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.