Free shipping on all orders over $ 500

Hyoscyamine

Cat. No. M2762
Hyoscyamine Structure
Synonym:

Daturine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
50mg USD 34  USD34 In stock
100mg USD 50  USD50 In stock
200mg USD 62  USD62 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.

Chemical Information
Molecular Weight 289.37
Formula C17H23NO3
CAS Number 101-31-5
Solubility (25°C) DMSO 48 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Prashanth Srinivasan, et al. Biosynthesis of medicinal tropane alkaloids in yeast

[2] No authors listed. Hyoscyamine

[3] No authors listed. Antiemetic Agents

[4] Neelesh Gupta. Hyoscyamine for a Slow Ventricular Response During Atrial Fibrillation

[5] Kathrin Laura Kohnen-Johannsen, et al. Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

Related AChR/AChE Products
Catestatin

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide.

α-Conotoxin MII

α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM.

COG 133 TFA

COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide.

α-Bungarotoxin

α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs).

G-Protein antagonist peptide

G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors.

  Catalog
Abmole Inhibitor Catalog




Keywords: Hyoscyamine, Daturine supplier, AChR/AChE, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.