Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
|Solubility (25°C)||Water ≥ 8 mg/mL|
|Storage||-20°C, protect from light, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Metabolite/Endogenous Metabolite Products|
2',3'-cGAMP sodium is an endogenous cGAMP in mammalian cells that binds STING with high affinity and is also a potent inducer of interferon-beta (IFNβ).2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.
Tryptophol (Indole-3-ethanol) is an endogenous metabolite.
DL-Tryptophan is an endogenous metabolite.
Tricosanoic acid is a long-chain fatty acid and shown to be a hair growth stimulant.
Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite.
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