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HWL-088

Cat. No. M11285

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HWL-088  Structure

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Quality Control & Documentation
Biological Activity

Hwl-088 is a highly effective, orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 18.9 nM) with moderate PPARδ activity (EC50 570.9 nM). Hwl-088 improves glucose and lipid metabolism.

Chemical Information
Molecular Weight 366.38
Formula C22H19FO4
CAS Number 2378617-96-8
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lijun Hu, et al. J Pharm Pharmacol. HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis

[2] Yueming Chen, et al. Br J Pharmacol. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice

[3] Zheng Li, et al. Bioorg Chem. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold

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  Catalog
Abmole Inhibitor Catalog




Keywords: HWL-088 supplier, inhibitors, activators

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