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(-)-Huperzine A

Cat. No. M3253
(-)-Huperzine A Structure
Synonym:

Huperzine A

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 34  USD34 In stock
10mg USD 48  USD48 In stock
50mg USD 166  USD166 In stock
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Quality Control
Biological Activity

(-)-Huperzine A is an Acetylcholinesterase inhibitor and NMDA receptor antagonist with an IC50 of 126 μM for NMDA-induced current. Huperzine A, is a naturally occurring sesquiterpene alkaloid compound found in the plant firmoss Huperzia serrata. The IC (50) values of huperzine A were neither altered by changing the concentrations of glycine (2-0.2 μM) and pH (7.4-6.7) in the external solution, nor by addition of Zn (2+) (5 μM) and dithiothreitol (5 mM) to the external solution.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Sprague-Dawley rats
Formulation Saline
Dosages 0.1 mg/kg
Administration Orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 242.32
Formula C15H18N2O
CAS Number 102518-79-6
Purity >99%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] Mara Jess Friedli, et al. Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease

[2] Nafiseh Ghassab-Abdollahi, et al. The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews

[3] Xiao Sang, et al. Research on endophytic fungi for producing huperzine A on a large-scale

[4] Guoyan Yang, et al. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials

[5] No authors listed. Drugs R D. Huperzine A

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