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Human PD-L1 inhibitor V

Cat. No. M21327
Human PD-L1 inhibitor V  Structure
Size Price Availability Quantity
10mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

Human PD-L1 inhibitor V is a human PD-1 protein binding peptide with a Kd value of 3.32 μM that inhibits the binding of human PD-1/PD-L1.Sequence:Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln.

Chemical Information
Molecular Weight 1485.71
Formula C65H104N20O18S
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Javier Cortes, et al. N Engl J Med. Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer

[2] Kohei Shitara, et al. Nature. Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

[3] Christine N Spencer, et al. Science. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

[4] Aditya Bardia, et al. N Engl J Med. Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

[5] Thomas Powles, et al. N Engl J Med. Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma

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Keywords: Human PD-L1 inhibitor V supplier, PD-1/PD-L1, inhibitors, activators

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