Human PD-L1 inhibitor V is a human PD-1 protein binding peptide with a Kd value of 3.32 μM that inhibits the binding of human PD-1/PD-L1.Sequence:Leu-Asp-Tyr-Val-Asn-Arg-Arg-Lys-Met-Tyr-Gln.
| Molecular Weight | 1485.71 |
| Formula | C65H104N20O18S |
| Solubility (25°C) | N/A |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related PD-1/PD-L1 Products |
|---|
| Genolimzumab
Genolimzumab is a PD-1 monoclonal antibody that can be used in studies related to peripheral T-cell lymphoma (PTCL). |
| TPP-1 hydrochloride
TPP-1 hydrochloride is a potent inhibitor of PD-1/PD-L1 interaction and binds specifically to PD-L1 with a Kd value of 95 nM.Can be used in tumor related studies. |
| CLP-002
CLP-002 is a low molecular weight anti-PD-L1 short peptide inhibitor, which can act by blocking the interaction between pd-1 and pd-l1, and thus can be used in tumor related studies. Sequence: WHRSYYTWNLNT |
| IMMH-010
IMMH-010 is a potent prodrug of the programmed cell death ligand 1 (PD-L1) inhibitor YPD-29B for studies related to oncology and neurological diseases. |
| MAX-10181
MAX-10181 (PD-1/PD-L1-IN-30) is a PD-1/PD-L1 binding inhibitor with an IC50 value of 0.018 μM.It can be used in studies related to solid tumors. |
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