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Homobrassinolide

Cat. No. M39607
Homobrassinolide Structure
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Biological Activity

Homobrassinolide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Information
Molecular Weight 494.7
Formula C29H50O6
CAS Number 74174-44-0
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mawra Khan et al. Plants (Basel). 28-Homobrassinolide Primed Seed Improved Lead Stress Tolerance in Brassica rapa L. through Modulation of Physio-Biochemical Attributes and Nutrient Uptake

[2] Shankarappa Sridhara et al. Saudi J Biol Sci. Application of homobrassinolide enhances growth, yield and quality of tomato

[3] Chuan He et al. Cytotechnology. Therapeutic effect of 28-homobrassinolide on leukotriene synthesis in leukemia cells

[4] Muthuraman Pandurangan et al. J Mol Recognit. Homobrassinolide induced conformational changes in hexokinase: a possible mechanism for its antidiabetic potential

[5] R Premalatha et al. Mol Biol Rep. 28-Homobrassinolide: a novel oxysterol transactivating LXR gene expression

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