HIV-1 protease-IN-10 has HIV-1 latency reversing activity (IC50: 0.22 μM).
Molecular Weight | 396.56 |
Formula | C23H40O5 |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Massimo Ciccozzi et al. New Microbiol. HIV-1 non-B subtypes in Italy: a growing trend
[4] Marius Trøseid et al. Curr HIV Res. High mobility group box protein-1 in HIV-1 infection
[5] Monique R Ferguson et al. Clin Lab Med. HIV-1 replication cycle
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