Heme Oxygenase-1-IN-1 (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM.
| Molecular Weight | 279.18 |
| CAS Number | 1093058-52-6 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Lisa Marie Schmitz, et al. Recent advances in heme biocatalysis engineering
[3] David A Gell. Structure and function of haemoglobins
[4] Tohru Fujiwara, et al. Biology of Heme in Mammalian Erythroid Cells and Related Disorders
[5] Andrew G Smith, et al. The regulatory role of heme in neurons
| Related Heme oxygenase Products |
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| Heme Oxygenase-1-IN-1 hydrochloride
Heme Oxygenase-1-IN-1 hydrochloride (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM. |
| Coniferaldehyde
Coniferaldehyde (Ferulaldehyde) is a potent inducer of heme oxygenase-1 (HO-1) with anti-inflammatory effects. In RAW264.7 macrophages, Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/βII/Nrf-2/HO-1-dependent pathway. |
| Zinc Protoporphyrin
Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. |
| Hemin chloride
Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis. |
| Tin protoporphyrin IX dichloride
Tin protoporphyrin IX dichloride is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model. |
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