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Heme Oxygenase-1-IN-1 hydrochloride

Cat. No. M14113
Heme Oxygenase-1-IN-1 hydrochloride Structure
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Biological Activity

Heme Oxygenase-1-IN-1 hydrochloride (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM.

Chemical Information
Molecular Weight 315.64
CAS Number 1092851-70-1
Solubility (25°C) DMSO 90 mg/mL
Water 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chunyan Wang, et al. Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

[2] Kang Mi Kim, et al. Induction of heme oxygenase‑1 expression protects articular chondrocytes against cilostazol‑induced cellular senescence

[3] Kang Mi Kim, et al. Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes

[4] Fei Yin, et al. GLP-1 receptor plays a critical role in geniposide-induced expression of heme oxygenase-1 in PC12 cells

[5] Mei-Hua Li, et al. Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling

Related Heme oxygenase Products
Heme Oxygenase-1-IN-1

Heme Oxygenase-1-IN-1 (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM.

Coniferaldehyde

Coniferaldehyde (Ferulaldehyde) is a potent inducer of heme oxygenase-1 (HO-1) with anti-inflammatory effects. In RAW264.7 macrophages, Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/βII/Nrf-2/HO-1-dependent pathway.

Zinc Protoporphyrin

Zinc Protoporphyrin is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor.

Hemin chloride

Hemin is an iron-containing porphyrinis potentially for the treatment of gastroparesis.

Tin protoporphyrin IX dichloride

Tin protoporphyrin IX dichloride is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

  Catalog
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Keywords: Heme Oxygenase-1-IN-1 hydrochloride supplier, Heme oxygenase, inhibitors, activators


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