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Helicid

Cat. No. M4684
Helicid Structure
Synonym:

Helicide; Helicidum; 4-Formylphenyl-β-D-allopyranoside

Size Price Availability Quantity
20mg USD 40  USD40 In stock
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Quality Control & Documentation
Biological Activity

The Helicid (Helicide) is the main component of the Helicia nilgirica Bedd. It can be used to promote stability, sleep and pain relief research, it is used in psychoneurosis related research.

Chemical Information
Molecular Weight 284.26
Formula C13H16O7
CAS Number 80154-34-3
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiao-Tong Zhang, et al. Helicid Reverses the Effect of Overexpressing NCALD, Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Model

[2] Yuan-Xiang Zhang, et al. Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation

[3] Yuanxiang Zhang, et al. Helicid Reverses Lipopolysaccharide-Induced Inflammation and Promotes GDNF Levels in C6 Glioma Cells through Modulation of Prepronociceptin

[4] Xu-Yi Li, et al. Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats

[5] Meng-Qi Zhang, et al. Helicid alleviates pain and sleep disturbances in a neuropathic pain-like model in mice

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Keywords: Helicid, Helicide; Helicidum; 4-Formylphenyl-β-D-allopyranoside supplier, inhibitors, activators
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