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HC-070

Cat. No. M14281

All AbMole products are for research use only, cannot be used for human consumption.

HC-070 Structure

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Quality Control & Documentation
Biological Activity

HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.

Chemical Information
Molecular Weight 475.32
CAS Number 1628291-95-1
Solubility (25°C) DMSO ≥ 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hong Wei, et al. Spinal TRPA1 Contributes to the Mechanical Hypersensitivity Effect Induced by Netrin-1

[2] Kangcheng Song, et al. Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

[3] Thomas Blum, et al. Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

[4] Stefan Just, et al. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

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  Catalog
Abmole Inhibitor Catalog




Keywords: HC-070 supplier, TRP Channel, inhibitors, activators

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