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In vitro: HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cells. In vivo: HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors.
| Cell Experiment | |
|---|---|
| Cell lines | A375 cells |
| Preparation method | Electron microscopic images of A375 cells treated for 24 hr with HA15 displayed membrane blebs characteristic of apoptotic cells。 |
| Concentrations | 10 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | female athymic nude mice |
| Formulation | |
| Dosages | 0.7 mg/mouse/day |
| Administration | i.v. |
| Molecular Weight | 466.58 |
| Formula | C23H22N4O3S2 |
| CAS Number | 1609402-14-3 |
| Solubility (25°C) | 73 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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