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H3B-120

Cat. No. M20722

All AbMole products are for research use only, cannot be used for human consumption.

H3B-120 Structure

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Quality Control & Documentation
Biological Activity

H3B-120 is a competitive, selective and allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits anti-tumor activity.

Chemical Information
Molecular Weight 372.48
Formula C19H24N4O2S
CAS Number 2194903-42-7
Solubility (25°C) DMSO 74 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ayumu Taguchi, et al. Cell Chem Biol. A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer

[2] Shihua Yao, et al. Cell Chem Biol. Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket

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Keywords: H3B-120 supplier, inhibitors, activators

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