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H2-Gamendazole

Cat. No. M42878

All AbMole products are for research use only, cannot be used for human consumption.

H2-Gamendazole Structure

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Quality Control & Documentation
Biological Activity

H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research.

Chemical Information
Molecular Weight 417.21
Formula C18H13Cl2F3N2O2
CAS Number 877768-84-8
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shabnam Pirestani et al. Am J Physiol Renal Physiol. H2-gamendazole: a new therapeutic lead for the treatment of polycystic kidney disease

[2] Shirin V Sundar et al. Am J Physiol Renal Physiol. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease

[3] Raymond K Hau et al. J Pharmacol Exp Ther. Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier

[4] Jean-Jacques Nya-Ngatchou et al. Contraception. New approaches to male non-hormonal contraception

[5] Robert L Matts et al. Bioorg Med Chem. A systematic protocol for the characterization of Hsp90 modulators

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