γ-Glu-Phe (γ-Glutamylphenylalanine) is a γ-3 glutamyl dipeptide synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). Proteolysis is an important factor for generation of γ-glutamyl dipeptides. Sensory evaluation of bread reveals that sourdough bread with higher concentrations of γ-glutamyl dipeptides ranks higher with respect to the taste intensity when compared to regular bread and type I sourdough bread.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water 45 mg/mL|
Synthesis and Sensory Characteristics of Kokumi γ-[Glu] n-Phe in the Presence of Glutamine and Phenylalanine: Glutaminase from Bacillus amyloliquefaciens or Aspergillus oryzae as the Catalyst
Juan Yang, et al. J Agric Food Chem. 2017 Oct 4;65(39):8696-8703. PMID: 28899090.
Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial
Jiaqi Huang, et al. Br J Cancer. 2016 Oct 25;115(9):1087-1095. PMID: 27673363.
Improvement of the bitter taste of amino acids through the transpeptidation reaction of bacterial gamma-glutamyltranspeptidase
Hideyuki Suzuki, et al. J Agric Food Chem. 2002 Jan 16;50(2):313-8. PMID: 11782200.
|Related Endogenous Metabolite Products|
N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite, it is the important constituent of brain heteropolysaccharides (glycoproteins).
Atranorin is a lichen secondary metabolite which shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical.
|Glutamic acid (L-Glutamic acid)
L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
D(+)-Xylose is a natural product, mainly used to produce xylitol, as a non-calorie sweetener in foods and beverages.
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