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H-Cys(Trt)-OH

Cat. No. M20502
H-Cys(Trt)-OH Structure
Synonym:

L-Cys(Trt)-OH, H-L-Cys(Trt)-OH, S-Tritylcysteine

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Biological Activity

H-Cys(Trt)-OH is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.

Chemical Information
Molecular Weight 363.47
Formula C22H21NO2S
CAS Number 2799-07-7
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] C M Gross, et al. J Pept Res. Preparation of protected peptidyl thioester intermediates for native chemical ligation by Nalpha-9-fluorenylmethoxycarbonyl (Fmoc) chemistry: considerations of side-chain and backbone anchoring strategies, and compatible protection for N-terminal cysteine

[2] M Koppitz, et al. Int J Pept Protein Res. Lipoconjugates: structure-activity studies for pheromone analogues of Ustilago maydis with varied lipophilicity

[3] S Horvat, et al. Int J Pept Protein Res. Synthesis and acid ionization constants of cyclic cystine peptides H-Cys-(Gly)n-Cys-OH (n = 0-4)

[4] W Wolff, et al. Hoppe Seylers Z Physiol Chem. [Synthesis of the fragments A1-8, A1-7, A9-15 and A8-15 of the chicken insulin A chain (author's transl)]

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Keywords: H-Cys(Trt)-OH, L-Cys(Trt)-OH, H-L-Cys(Trt)-OH, S-Tritylcysteine supplier, inhibitors, activators

 
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