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GYY4137

Cat. No. M20830

All AbMole products are for research use only, cannot be used for human consumption.

GYY4137 Structure
Size Price Availability Quantity
5mg USD 35  USD35 In stock
10mg USD 55  USD55 In stock
25mg USD 90  USD90 In stock
50mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.

Chemical Information
Molecular Weight 376.47
Formula C11H16NO2PS2.C4H9NO
CAS Number 106740-09-4
Solubility (25°C) DMSO 85 mg/mL
Water 15 mg/mL
Storage -20°C, sealed
References

[1] Tao Zhou, et al. Biochim Biophys Acta Mol Basis Dis. GYY4137 ameliorates sepsis-induced cardiomyopathy via NLRP3 pathway

[2] Wei Cui, et al. FASEB J. GYY4137 protected the integrity of the blood-brain barrier via activation of the Nrf2/ARE pathway in mice with sepsis

[3] Hongmei Zhao, et al. Kidney Blood Press Res. Protective Effects of GYY4137 on Renal Ischaemia/Reperfusion Injury through Nrf2-Mediated Antioxidant Defence

[4] Lei Jiang, et al. Pulm Pharmacol Ther. GYY4137 attenuates LPS-induced acute lung injury via heme oxygenase-1 modulation

[5] Peter Rose, et al. Methods Enzymol. GYY4137, a novel water-soluble, H2S-releasing molecule

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Keywords: GYY4137 supplier, STAT, inhibitors, activators

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