Free shipping on all orders over $ 500

GSK8175

Cat. No. M28392

All AbMole products are for research use only, cannot be used for human consumption.

GSK8175 Structure
Synonym:

GSK2878175

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons.

Chemical Information
Molecular Weight 568.81
Formula C27H23BClFN2O6S
CAS Number 1423007-82-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Peng Zhan, et al. J Med Chem. Resurrecting the Condemned: Identification of N-Benzoxaborole Benzofuran GSK8175 as a Clinical Candidate with Reduced Metabolic Liability

[2] Pek Y Chong, et al. J Med Chem. Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

[3] Kenneth Arrington, et al. J Org Chem. Convergent Synthesis of the NS5B Inhibitor GSK8175 Enabled by Transition Metal Catalysis

Related Anti-infection Products
Torcitabine

Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection research. Torcitabine (2'-Deoxy-L-cytidine) shows greater inhibition of first strand than second strand DNA synthesis.

ABMA

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite.

DDX3-IN-1

DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50 values of 50 and 36 μM for HIV and HCV, respectively. DDX3-IN-1 has antiviral activity.

WU-04 

WU-04 is a non-covalent inhibitor of SARS-CoV-2, targeting the 3CLpro protein.

MM3122 

MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: GSK8175, GSK2878175 supplier, Anti-infection, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.