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Gomisin S

Cat. No. M19292
Gomisin S Structure
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5mg USD 800  USD800 In stock
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Biological Activity

Gomisin S is a dibenzocyclooctadiene lignan.

Chemical Information
Molecular Weight 418.48
Formula C23H30O7
CAS Number 119239-49-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Namkyung Kim, et al. Mol Med Rep. Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways

[2] Jinjoo Kang, et al. Molecules. Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/ Dermatophagoides farinae Extract-Induced BALB/c Mice

[3] Xiaoyong Zheng, et al. Molecules. A Rapid UPLC-MS Method for Quantification of Gomisin D in Rat Plasma and Its Application to a Pharmacokinetic and Bioavailability Study

[4] Samil Jung, et al. Oncol Rep. Anticancer activity of gomisin J from Schisandra chinensis fruit

[5] Chi-Keung Wan, et al. Biochem Pharmacol. Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells

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