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GNE-900 

Cat. No. M27924

All AbMole products are for research use only, cannot be used for human consumption.

GNE-900  Structure

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Quality Control & Documentation
Biological Activity

GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 µM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. gemcitabine and GNE-900 administration shows anti-tumor activity.

Chemical Information
Molecular Weight 367.45
Formula C23H21N5
CAS Number 1200126-26-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Joanne Wayne, et al. Oncotarget. Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase

[2] Lewis Gazzard, et al. J Med Chem. Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1

[3] Yang Xiao, et al. Mol Cancer Ther. Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor

[4] Elizabeth Blackwood, et al. Mol Cancer Ther. Combination drυg scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900

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  Catalog
Abmole Inhibitor Catalog




Keywords: GNE-900  supplier, Checkpoint, inhibitors, activators

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