Free shipping on all orders over $ 500

GNE-0946 

Cat. No. M28800

All AbMole products are for research use only, cannot be used for human consumption.

GNE-0946  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.

Chemical Information
Molecular Weight 460.79
Formula C22H12ClF3N2O4
CAS Number 1677667-24-1
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Benjamin P Fauber, et al. Bioorg Med Chem Lett. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists

Related ROR Products
ASN06917370 

ASN06917370 is a former orphan receptor GPR17 ligand for the study of neurodegenerative diseases.

JTE-151

JTE-151 is a RORγ inhibitor that suppresses overactive immune responses by inhibiting RORγ associated with Th17 cell activation.JTE-151 can be used in studies related to autoimmune diseases.

SAR-441169

SAR-441169 is a RORγt inverse agonist that can be used in studies related to psoriasis.

GRC-39815

GRC-39815 is a RORγt inverse agonist that can be used in studies related to chronic obstructive pulmonary disease.

RORγ antagonist 1

RORγ antagonist 1, a potent betulinic acid derivative, is an antagonist of RORγ (KD=0.18 μM).

  Catalog
Abmole Inhibitor Catalog




Keywords: GNE-0946  supplier, ROR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.