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Glycol chitosan

Cat. No. M19968
Glycol chitosan Structure
Synonym:

Glycol chitin; deacetylated

Size Price Availability Quantity
100mg USD 48  USD48 In stock
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Quality Control
  • Current batch:
  • Purity >60%
  • COA
  • MSDS
Biological Activity

Glycol chitosan is a kind of chitosan derivative with hydrophilic glycol-branched. Glycol-chitosan enhances membrane permeability and lead in glycine Max Harosoy 63W cells. Glycol-chitosan has water solubility, biocompatibility and biodegradability. The inhibitory MIC values of ethylene glycol chitosan against Escherichia coli, Staphylococcus aureus and Salmonella enteritidis were 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 633.64
Formula C24H47N3O16
CAS Number 123938-86-3
Purity >60%
Solubility DMSO ≥ 40 mg/mL
Water 7.5 mg/mL
Storage at -20°C
References

[1] Fengming Lin, et al. Molecules . Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery

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Keywords: Glycol chitosan, Glycol chitin; deacetylated supplier, Anti-infection, inhibitors

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