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GluR23Y

Cat. No. M43344
GluR23Y Structure
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Biological Activity

GluR23Y is a biological active peptide.

Chemical Information
Molecular Weight 1092.16
Formula C51H69N11O16
CAS Number 696659-27-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fatemeh Ashourpour et al. Metab Brain Dis. Chronic administration of Tat-GluR23Y ameliorates cognitive dysfunction targeting CREB signaling in rats with amyloid beta neurotoxicity

[2] Fatemeh Ashourpour et al. Int J Neurosci. Co-treatment of AMPA endocytosis inhibitor and GluN2B antagonist facilitate consolidation and retrieval of memory impaired by β amyloid peptide

[3] Yang-Jung Yu et al. Neurobiol Learn Mem. AMPA receptor endocytosis in the amygdala is involved in the disrupted reconsolidation of Methamphetamine-associated contextual memory

[4] Ting-Ting Duan et al. Psychopharmacology (Berl). Acute ketamine induces hippocampal synaptic depression and spatial memory impairment through dopamine D1/D5 receptors

[5] Hui-Ching Lin et al. Int J Neuropsychopharmacol. Alterations of excitatory transmission in the lateral amygdala during expression and extinction of fear memory

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Keywords: GluR23Y supplier, inhibitors, activators

 
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