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Glembatumumab

Cat. No. M24535

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Glembatumumab Structure
Size Price Availability Quantity
100u USD 220  USD220 In stock
1mg USD 410  USD410 In stock
5mg USD 820  USD820 In stock
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Quality Control & Documentation
Biological Activity

Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-drug coupling (ADC) with antitumor activity.

Immobilized human GPNMB his at 2 ug/mL can bind glembatumumab, the EC50 is 0.01720 ug/mL.

Chemical Information
CAS Number 1020264-78-1
Storage Store at ≤ -20℃ for up to 24 months. Avoid repeated freeze-thaw cycles.
References

[1] Marco Biondini, et al. Oncogene. HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin

[2] Linda T Vahdat, et al. NPJ Breast Cancer. Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer ("METRIC"): a randomized multicenter study

[3] April A N Rose, et al. Pharmacol Ther. Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer

[4] Christopher H Keir, et al. Expert Opin Biol Ther. The use of an antibody drυg conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer

[5] Louie Naumovski, et al. Curr Opin Mol Ther. Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer

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Keywords: Glembatumumab supplier, inhibitors, activators

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