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Glaucocalyxin A

Cat. No. M9912
Glaucocalyxin A Structure
Size Price Availability Quantity
5mg USD 320  USD320 In stock
10mg USD 540  USD540 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Glaucocalyxin A is an ent-kauranoid diterpene from Rabdosia japonica var. Glaucocalyxin A induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 332.43
Formula C20H28O4
CAS Number 79498-31-0
Purity >99%
Solubility DMSO 80 mg/mL
Storage -20°C, dry, sealed
References

[1] Jianwei Zhu, et al. Cell Death Dis. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway

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  Catalog
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Keywords: Glaucocalyxin A supplier, PI3K, inhibitors

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