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Gitoxin

Cat. No. M39032

All AbMole products are for research use only, cannot be used for human consumption.

Gitoxin Structure

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Quality Control & Documentation
Biological Activity

Gitoxin, a Na+/K+-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably.

Chemical Information
Molecular Weight 780.94
Formula C41H64O14
CAS Number 4562-36-1
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] L Muthuselvi et al. Colloids Surf B Biointerfaces. Simple coacervates of zein to encapsulate Gitoxin

[2] Danijela Krstić et al. J Enzyme Inhib Med Chem. Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase

[3] K O Haustein et al. Pharmacology. Studies on cardioactive steroids. V. Structure-activity relationships of derivatives of 16 alpha-gitoxin

[4] P L Pellegrin et al. Eur J Drug Metab Pharmacokinet. A further study of the pharmacokinetics of gitoxin in rabbit isolated liver: clearance of 3H-gitoxin

[5] P Pellegrin et al. J Pharm Belg. A new alternative in the field of cardiac glycosides: gitoxin

Related ATPase Products
Apoptolidin 

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria.

Transdermal Peptide Disulfide

Transdermal Peptide Disulfide (TD 1 Disulfide(peptide)) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1.

SPAI-1

SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases.

Prilocaine acetate

Prilocaine acetate, an amino amide, is a Na/K-ATPase inhibitor.

Chamigrenol

Chamigrenol is a Na+/K+-ATPase inhibitor with an IC50 value of 15.9 μg/mL.

  Catalog
Abmole Inhibitor Catalog




Keywords: Gitoxin supplier, ATPase, inhibitors, activators

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