Free shipping on all orders over $ 500

GFB-887

Cat. No. M43953

All AbMole products are for research use only, cannot be used for human consumption.

GFB-887 Structure
Synonym:

KAR-2618

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

GFB-887 is an inhibitor of transient receptor potential channels 4 and 5 (TRPC4/5) and can be used in studies related to anxiety disorders.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Amy D Westerling-Bui, et al. Sci Adv. Transplanted organoids empower human preclinical assessment of drug candidate for the clinic

[2] Liron Walsh, et al. Kidney Int Rep. Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy: TRACTION-2 Trial Design

Related TRP Channel Products
PF-04745637

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1.

Phenazopyridine

Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine can promote neuronal differentiation and it can also be used in the research of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases.

4-ONE

4-ONE is one of the major hemolytic decomposition products of lipid hydroperoxides. 4-ONE is a potent transient receptor potential ankyrin 1 (TRPA1) agonist.

Moringin

Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8.

(S)-ABT-102

(S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin.

  Catalog
Abmole Inhibitor Catalog




Keywords: GFB-887, KAR-2618 supplier, TRP Channel, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.