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GDC-0853 (Fenebrutinib)

Cat. No. M8941
GDC-0853 (Fenebrutinib) Structure
Synonym:

Fenebrutinib; RG7845

Size Price Availability Quantity
10mg USD 153  USD170 In stock
50mg USD 603  USD670 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

GDC-0853 (Fenebrutinib) is a potent and orally BTK inhibitor. GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 664.8
Formula C37H44N8O4
CAS Number 1434048-34-6
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage 2-8°C, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GDC-0853 (Fenebrutinib), Fenebrutinib; RG7845 supplier, BTK, inhibitors

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