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Fenebrutinib

Cat. No. M8941

All AbMole products are for research use only, cannot be used for human consumption.

Fenebrutinib Structure
Synonym:

GDC-0853; RG7845

Size Price Availability Quantity
10mM*1mL in DMSO USD 127  USD127 In stock
2mg USD 60  USD60 In stock
5mg USD 95  USD95 In stock
10mg USD 170  USD170 In stock
25mg USD 370  USD370 In stock
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Quality Control & Documentation
Biological Activity

GDC-0853 (Fenebrutinib) is a potent, selective and non-covalent bruton tyrosine kinase (Btk) inhibitor with a Ki value of 0.91 nM against BRK. GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK.

Chemical Information
Molecular Weight 664.8
Formula C37H44N8O4
CAS Number 1434048-34-6
Solubility (25°C) DMSO 20 mg/mL
Storage 2-8°C, sealed
References

[1] H Yesid Estupin, et al. Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

[2] Ayse Bag-Ozbek, et al. Emerging B-Cell Therapies in Systemic Lupus Erythematosus

[3] Kirti J Johal, et al. Current and emerging treatments for chronic spontaneous urticaria

[4] Pavel Kolkhir, et al. New treatments for chronic urticaria

[5] James J Crawford, et al. Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development

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BIIB129 is a covalent, selective inhibitor of Bruton's tyrosine kinase (BTK) capable of penetrating the blood-brain barrier. BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK, thereby affecting the function of B cells and myeloid cells.

UBX-382 

UBX-382 is an orally available proteolysis-targeting chimeras (PROTACs) that target BTK to inactivate B-cell receptor signaling.

GDC-0834 

GDC-0834 is a potent and selective BTK inhibitor.

DD-03-171 

DD-03-171 is a BTK, IKFZ1 and IKFZ3 degrader, the BTK IC50 a value of 5.1 nM.

N-piperidine Ibrutinib hydrochloride 

N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative.

  Catalog
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Keywords: Fenebrutinib, GDC-0853; RG7845 supplier, BTK, inhibitors, activators

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