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GDC-0425

Cat. No. M27925

All AbMole products are for research use only, cannot be used for human consumption.

GDC-0425 Structure
Synonym:

RG-7602

Price and Availability

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Quality Control & Documentation
Biological Activity

GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies.

Chemical Information
Molecular Weight 321.38
Formula C18H19N5O
CAS Number 1200129-48-1
Form Solid
Solubility (25°C) Water 25 mg/mL (ultrasonic and adjust pH to 3 with HCl)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ryan H Takahashi, et al. Drug Metab Dispos. Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

[2] Ho-June Lee, et al. Mol Cancer Ther. Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

[3] Jeffrey R Infante, et al. Clin Cancer Res. Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors

[4] Xiao Ding, et al. Biomed Chromatogr. A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma

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Keywords: GDC-0425, RG-7602 supplier, Checkpoint, inhibitors, activators

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