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GBR-12935

Cat. No. M3248

All AbMole products are for research use only, cannot be used for human consumption.

GBR-12935 Structure
Synonym:

GBR12935

Size Price Availability Quantity
10mg USD 70  USD70 In stock
50mg USD 180  USD180 In stock
100mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. GBR-12935 is now widely used in animal research into Parkinson’s disease and the dopamine pathways in the brain.

Chemical Information
Molecular Weight 414.58
Formula C28H34N2O
CAS Number 76778-22-8
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] I Gordon, et al. [3H]GBR 12935 labels mainly the piperazine acceptor site in the rat prefrontal cortex

[2] A Janowsky, et al. [3H]GBR-12935 binding to the dopamine transporter is decreased in the caudate nucleus in Parkinson's disease

[3] P H Andersen, et al. [3H]GBR 12935 binding in vivo in mouse brain: labelling of a piperazine acceptor site

[4] M Hirai, et al. [3H]GBR-12935 binding sites in human striatal membranes: binding characteristics and changes in parkinsonians and schizophrenics

[5] J Marcusson, et al. [3H]GBR-12935 binding to dopamine uptake sites in the human brain

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Keywords: GBR-12935, GBR12935 supplier, inhibitors, activators

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