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GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. GBR-12935 is now widely used in animal research into Parkinson’s disease and the dopamine pathways in the brain.
| Molecular Weight | 414.58 |
| Formula | C28H34N2O |
| CAS Number | 76778-22-8 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] J Marcusson, et al. [3H]GBR-12935 binding to dopamine uptake sites in the human brain
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