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GBR 12935 dihydrochloride is a potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes). GBR 12935 dihydrochloride also inhibit dopamine uptake into brain synaptic vesicles. The binding of GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms. In vivo, GBR 12935 elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg.
| Molecular Weight | 487.51 |
| Formula | C28H34N2O.2HCl |
| CAS Number | 67469-81-2 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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