Free shipping on all orders over $ 500

Gboxin

Cat. No. M10261
Gboxin Structure
Synonym:

Gboxin chloride

Size Price Availability Quantity
5mg USD 298  USD298 In stock
10mg USD 442  USD442 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma, inhibits the activity of F0F1 ATP synthase, with antitumour activity. Gboxin rapidly and irreversibly compromises oxygen consumption in glioblastoma cells. Gboxin relies on its positive charge to associate with mitochondrial oxidative phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane. Gboxin-resistant cells require a functional mitochondrial permeability transition pore that regulates pH and thus impedes the accumulation of Gboxin in the mitochondrial matrix.

Chemical Information
Molecular Weight 392.96
Formula C22H33ClN2O2
CAS Number 2101315-36-8
Solubility (25°C) DMSO 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yufeng Shi, et al. Nature. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

Related ATPase Products
BRITE338733

BRITE-338733 is a potent RecA (a DNA-dependent ATPase) inhibitor with IC50 of 4.7 µM.

ML241 hydrochloride

ML241 hydrochloride is a potent and selective inhibitor of p97 with IC50 of 0.11 μM and 3.5 μM for p97 ATPase and UbG76V–GFP, respectively.

Tegoprazan

Tegoprazan (CJ-12420, IN-A001, K-CAB, LXI-15028) is a potassium-competitive acid blocker and a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.

ML367

ML367 is an inhibitor of ATAD5 stabilization.

NDI-091143

NDI-091143 is a novel potent inhibitor of human ATP-citrate lyase with an IC50 of 2.1 nM (ADP-Glo assay).

  Catalog
Abmole Inhibitor Catalog




Keywords: Gboxin, Gboxin chloride supplier, ATPase, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.