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Cat. No. M21026
Garenoxacin Structure

T-3811ME, BMS-284756

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Biological Activity

Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.

Chemical Information
Molecular Weight 426.41
Formula C23H20F2N2O4
CAS Number 194804-75-6
Solubility (25°C) DMSO 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Ajitha Azhakesan, et al. J AOAC Int. QbD-Based Development and Validation of Novel Stability-Indicating Method for the Assay and Dissolution of Garenoxacin in Garenoxacin Tablets

[2] Hiroki Yamada, et al. J Infect Chemother. The clinical efficacy of garenoxacin for male non-gonococcal urethritis

[3] Togo Aoyama, et al. Hemodial Int. Garenoxacin pharmacokinetics in patients undergoing maintenance hemodialysis

[4] Agam Vora. J Assoc Physicians India. Garenoxacin

[5] Hiroyasu Takagi, et al. Int J Antimicrob Agents. Clinical studies of garenoxacin

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Keywords: Garenoxacin, T-3811ME, BMS-284756 supplier, Anti-infection, inhibitors, activators

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