Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes.
|Solubility (25°C)||DMSO 2 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Anti-infection Products|
Fomivirsen is a phosphorothioate oligonucleotide derivative that binds to and degrades the mRNA of the CMV immediate-early 2 protein, thereby inhibiting viral proliferation, and can be used in studies related to cytomegalovirus retinitis (CMV).
Bucillamine is an orally active endogenous cysteine derivative of the amino acid that also acts as a sulfhydryl donor with antiangiogenic, antioxidant, and anti-inflammatory activities, and is used in rheumatoid arthritis (RA), cystinuria, and gout studies.
β-Amyrin acetate is a triterpenoid natural product that localizes to HMG CoA reductase and inhibits its activity, with potent anti-inflammatory, anti-fungal, anti-diabetic, and anti-hyperlipidemic activities.
|Rabbit defensin NP-1
Rabbit defensin NP-1, a defensin isolated from rabbit neutrophils, consists of 33 amino acids rich in arginine and cysteine residues and has antimicrobial activity.
Human β-defensin-3 is an antimicrobial peptide produced by epithelial cells that reduces inflammatory cytokine responses, as well as inhibits microbial growth, and has immunomodulatory activity with IC90 values ranging from 6-25 μg/ml.
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