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Garcinone B

Cat. No. M42285
Garcinone B Structure
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Quality Control & Documentation
Biological Activity

Garcinone B, a xanthone derivative, is a nature product that could be isolated from the pericarp of Mangosteen.

Chemical Information
Molecular Weight 394.42
Formula C23H22O6
CAS Number 76996-28-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Cecep Suhandi et al. Molecules. Potency of Xanthone Derivatives from Garcinia mangostana L. for COVID-19 Treatment through Angiotensin-Converting Enzyme 2 and Main Protease Blockade: A Computational Study

[2] Suthinee Sangkanu et al. Acta Trop. Phytochemical, anti-Acanthamoeba, and anti-adhesion properties of Garcinia mangostana flower as preventive contact lens solution

[3] Aravindakshanpillai P Anu Aravind et al. Nat Prod Commun. Phytochemical Screening of Garcinia travancorica by HPLC-ESI-QTOF Mass Spectrometry and Cytotoxicity Studies of the Major Biflavonoid Fukugiside

[4] Tohru Yamakuni et al. Neurosci Lett. Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells

[5] Sunit Suksamrarn et al. J Nat Prod. Xanthones from the green fruit hulls of Garcinia mangostana

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