Garcinol is a kind of polyisoprene diphenylketone extracted from Garcinia japonicum. It has anticholinesterase properties for AChE and butyrylcholinesterase (BChE) with IC50 of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibited histone acetyltransferases (HATs, IC50=7 μM) and P300 /CPB related factors (PCAF, IC50=5 μM). Garcinol has anti-inflammatory and anticancer activities.
| Molecular Weight | 602.8 |
| Formula | C38H50O6 |
| CAS Number | 78824-30-3 |
| Solubility (25°C) | DMSO 45 mg/mL Ethanol 20 mg/mL |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Se In Son, et al. ACS Chem Biol. Garcinol Is an HDAC11 Inhibitor
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