Ganirelix acetate is a competitive gonadotropin-releasing hormone (GnRH) antagonist that directly binds to endogenous molecules competing for the receptor and causes a rapid decrease in estradiol levels. Ganirelix acetate can be used in studies related to ovarian hyperstimulation syndrome (OHSS) and preterm labor.
| Molecular Weight | 1690.42 |
| Formula | C84H121ClN18O17 |
| CAS Number | 129311-55-3 |
| Form | Solid |
| Solubility (25°C) | Water 50 mg/mL |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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|---|
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Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). |
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Luteinizing Hormone Releasing Hormone (LH-RH), salmon (Salmon GnRH) is the hypophysiotropic decapeptide synthesized in the hypothalamus that plays a crucial role in the control of reproductive functions. |
| Phoenixin-14
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| LGnRH-III, lamprey
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