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Ganciclovir sodium

Cat. No. M19956
Ganciclovir sodium Structure
Size Price Availability Quantity
100mg USD 72  USD72 In stock
1g USD 115  USD115 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ganciclovir sodium is an antiviral medication used to treat cytomegalovirus (CMV) infections

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 277.21
Formula C9H12N5NaO4
CAS Number 107910-75-8
Purity >99%
Solubility DMSO 55 mg/mL
Water 55 mg/mL
Storage at -20°C
References

[1] Raymund R Razonable. Curr Pharm Des. Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions

[2] Abdullah A Al-Badr, et al. Profiles Drug Subst Excip Relat Methodol. Ganciclovir

[3] C N Kotton. Am J Transplant. CMV: Prevention, Diagnosis and Therapy

[4] G C Visor, et al. Am J Hosp Pharm. Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections

[5] W Brooks. Aust Nurses J. Ganciclovir

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