All AbMole products are for research use only, cannot be used for human consumption.
FX-11 (LDHA Inhibitor FX11) is a potent lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 23.3 μM for HeLa cell and a Ki value of 8 μM. FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death.
FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. FX-11 (2.1 mg/kg; IP; administered daily for 10-14 days) suppresses P493 tumor growth.
| Molecular Weight | 350.41 |
| Formula | C22H22O4 |
| CAS Number | 213971-34-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 150 mg/mL |
| Storage | Powder -20°C |
| Related LDH Products |
|---|
| Nedosiran sodium
Nedosiran sodium is a GalNAc-dsRNA conjugate designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme. |
| MS6105
MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) with anticancer activity for studies related to pancreatic cancer. |
| CHK-336
CHK-336 is an inhibitor of the lactate dehydrogenase LDHA and can be used in studies related to primary hyperoxaluria. |
| (R)-GNE-140
(R)-GNE-140 is a selective inhibitor of LDHA and LDHB with IC50 of 3 nM and 5 nM, respectively. (R)-GNE-140 is 18 times more potent than its S-type isomer. |
| GNE-140 racemate
GNE-140 racemate is a racemic mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is also a potent lactate dehydrogenase A (LDHA) inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
