About 28 results found for searched term "LDH" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9849 | AZ-33 | LDH |
| AZ33; LDHA Inhibitor 33 | ||
| AZ-33 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50 of 0.5 μM. | ||
| M14457 | FX-11 | LDH |
| LDHA Inhibitor FX11 | ||
| FX-11 (LDHA Inhibitor FX11) is a potent lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 23.3 μM for HeLa cell and a Ki value of 8 μM. FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. | ||
| M31314 | D-Lactate dehydrogenase | Dehydrogenase |
| D-LDH; EC 1.1.1.28 | ||
| D-Lactate dehydrogenase is an oxidoreductase widely found in bacteria and fungi that acts on donor CH-OH groups using NAD+ or NADP+ as an acceptor and also catalyzes the oxidation of D-lactate to pyruvate. | ||
| M3313 | Teniposide | Topoisomerase |
| VM26 | ||
| Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). | ||
| M3390 | Disulfiram | Pyroptosis |
| Tetraethylthiuram disulfide; TETD | ||
| Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1). Disulfiram is used in the study of chronic alcoholism, with acute sensitivity to alcohol, and is a potent copper ion-carrier that can be used in cuproptosis studies. | ||
| M3706 | CVT-10216 | ALDH |
| CVT-10216 is a highly selective, reversible inhibitor of ALDH-2 that reduces excessive alcohol drinking. | ||
| M6384 | A37 | ALDH |
| A37 is a aLDH1A1 inhibitor. | ||
| M6771 | GSK 2837808A | LDH |
| GSK 2837808A is a potent, selective LDHA inhibitor. | ||
| M7487 | WIN 18446 | ALDH |
| WIN 18446 is a aLDH1a2 inhibitor. | ||
| M25611 | Cyclosomatostatin acetate | Somatostatin Receptor |
| cycloSST | ||
| Cyclosomatostatin acetate is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin acetate can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells. | ||
| M8543 | NHI-2 | LDH |
| NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). | ||
| M8781 | NCT-501 | ALDH |
| NCT-501 is a potent and selective inhibitor of Aldehyde dehydrogenase ALDH1A1, a dehydrogenase that has been found to be elevated in certain cancers and in cancer stem cells. | ||
| M9783 | Sodium oxamate | LDH |
| Oxamic acid sodium salt | ||
| Sodium oxamate is a competitive LDHA (actate dehydrogenase A) inhibitor, it inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway. | ||
| M10743 | GNE-140 racemate | LDH |
| GNE-140 racemate is a racemic mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is also a potent lactate dehydrogenase A (LDHA) inhibitor. | ||
| M10771 | (R)-GNE-140 | LDH |
| (R)-GNE-140 is a selective inhibitor of LDHA and LDHB with IC50 of 3 nM and 5 nM, respectively. (R)-GNE-140 is 18 times more potent than its S-type isomer. | ||
| M20768 | CM10 | ALDH |
| CM10 is a potent and selective inhibitor of aldehyde dehydrogenase 1A family (ALDH1A) with IC50 of 1700 nM, 740 nM and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively. CM10 exhibits anti-cancer activity. | ||
| M29205 | EN40 | ALDH |
| EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM. | ||
| M29799 | IGUANA-1 free base | ALDH |
| STL5-T-0057 | ||
| IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer. | ||
| M29800 | IGUANA-1 | ALDH |
| IGUANA-1 is a potent inhibitor of ALDH1B1, which is a mitochondrial enzyme that promotes colorectal and pancreatic cancer. IGUANA-1 has significant inhibition against cancer cells. | ||
| M30042 | Cholesterol 5beta,6beta-epoxide | Others |
| Cholesterol beta-epoxide | ||
| Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Cholesterol 5beta,6beta-epoxide induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. | ||
| M31093 | RV01 | ALDH |
| RV01 is a novel quinolyl-substituted analogue of resveratrol, it inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol. RV01 exhibits hydroxyl radical scavenging activity. | ||
| M31417 | CHK-336 | LDH |
| CHK-336 is an inhibitor of the lactate dehydrogenase LDHA and can be used in studies related to primary hyperoxaluria. | ||
| M31418 | MS6105 | LDH |
| MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) with anticancer activity for studies related to pancreatic cancer. | ||
| M39154 | Isomalt | Dehydrogenase |
| Isomalt (Palatinitol) stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry. | ||
| M40892 | Acetaldehyde | TRP Channel |
| Acetaldehyde is a TRP anchor protein 1 (TRPA1) agonist that is converted to non-toxic acetic acid by acetaldehyde dehydrogenase (ALDH). | ||
| M42453 | Nedosiran sodium | LDH |
| Nedosiran sodium is a GalNAc-dsRNA conjugate designed to inhibit production of the hepatic lactate dehydrogenase (LDH) enzyme. | ||
| M49483 | B-355252 | Apoptosis |
| B-355252 is a phenoxythiophene sulfonamide small molecule and a potent NGF receptor agonist that enhances NGF-induced neurite growth. It also protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and LDH levels, and preventing neuronal apoptosis. In addition, B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity and in a mouse hippocampal cell line (HT22) model of Parkinson's disease (PD). | ||
| M54718 | PP405 | Others |
| PP405 is a potent localized mitochondrial pyruvate carrier (MPC) inhibitor that acts on cellular metabolic pathways to up-regulate LDH and activate stem cells to promote hair growth, and can be used in studies related to androgenetic alopecia. | ||
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